Evidence-based Medicine and Clinical Study Designs: Examples of Applications for Allergy Research
Simon F. Thomsen*
Identifiers and Pagination:Year: 2014
First Page: 1
Last Page: 9
Publisher Id: TOALLJ-7-1
Article History:Received Date: 28/2/2014
Revision Received Date: 7/7/2014
Acceptance Date: 15/7/2014
Electronic publication date: 8/9/2014
Collection year: 2014
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Evidence of the effect of clinical interventions in allergology, and in medicine as a whole, can be hierarchically grouped based on the research design producing the evidence. The most weight is given to systematic reviews and metaanalyses, and to randomised controlled trials. These trial designs are superior to non-randomised controlled trials and cohort studies, which in turn are superior to case-control studies. The least weight is given to case-studies and anecdotal evidence. Herein, the principles of evidence-based medicine and clinical study designs are reviewed in the context of examples from the allergology literature.