Anaphylaxis After Ingesting Ibuprofen Liquid Gelatin-Capsule

Fahad Al-Ghimlas*, 1, Nasser Al-Ahmed2, Sean Mace3
1 Chest Unit, Department of Medicine, Amiri Hospital, Ministry of Health, State of Kuwait
2 Department of Allergy, Al-Rashed Allergy Centre, Ministry of Health, State of Kuwait
3 Division of Allergy and Clinical Immunology, Department of Medicine, St. Michael's Hospital, University of Toronto, Canada

© 2012 Al-Ghimlas et al;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Chest Unit, Department of Medicine, Amiri Hospital, P.O.Box 39810 Nuzha, Postal Code 73059; Tel: +(965) 22464725; Fax: +(965) 22435861; E-mail:


Non-steroidal anti-inflammatory drugs are used daily by millions of patients worldwide for the management of various inflammatory diseases. Many well-documented adverse reactions are related to the use of these drugs. We report a fifty-four year-old woman with anaphylaxis after ingestion of ibuprofen liquid in a gelatin capsule. Eventually this was concluded to have resulted from hypersensitivity to the gelatin component of the capsule, which was likely IgE-mediated because of the positive skin test to gelatin. Gelatin allergy is only relevant for patients ingesting specific capsule formulation. The allergist/clinical immunologist must keep in mind the possibility of gelatin allergy.

Keywords: Anaphylaxis, Gelatin, Ibuprofen, Non-steroidal anti-inflammatory drugs.