Human Basophil Phenotypes and the Associated Signaling Mechanisms
Donald MacGlashan, Jr.*
Identifiers and Pagination:Year: 2010
First Page: 60
Last Page: 72
Publisher Id: TOALLJ-3-60
Article History:Received Date: 14/2/2010
Revision Received Date: 7/5/2010
Acceptance Date: 12/5/2010
Electronic publication date: 26/11/2010
Collection year: 2010
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A variety of studies have shown that human basophils are participants in allergic reactions and a recent study has indicated that it may even be important in the immediate reaction generally associated with a mast cell response. Therefore, it is important to understand how the function of these cells is regulated and whether the functionality has a relationship to the presence and severity of diseases like atopy. There are many indications that for IgE-mediated secretion, the regulation of syk expression is relevant to the broad distribution of outcomes observed in the general population. The factors influencing the expression of syk will be explored. In addition the outcomes of studies surveying signal element expression by various methods will be discussed.