New Insights into the Molecular Basis of the House Dust Mite-Induced Allergic Response



Alain Jacquet*
Chulalongkorn University, Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Oor-Por-Ror Building, 10th floor, Room # 1010/5, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand.


Article Metrics

CrossRef Citations:
0
Total Statistics:

Full-Text HTML Views: 140
Abstract HTML Views: 47
PDF Downloads: 63
Total Views/Downloads: 250
Unique Statistics:

Full-Text HTML Views: 96
Abstract HTML Views: 36
PDF Downloads: 47
Total Views/Downloads: 179



© 2009 Alain Jacquet;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Chulalongkorn University, Division of Allergy and Clinical Immunology, Department of Medicine,Faculty of Medicine, Oor-Por-Ror Building, 10th floor, Room # 1010/5, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand; Tel: +6622564579; Fax: +6626523100; E-mail: alain.j@chula.ac.th


Abstract

House dust mite (HDM) represents world-wide one of the most common source of aeroallergens word-wide and more than 50% of allergic patients are sensitized to these allergenic molecules. Although the induction of specificTh2 cells as well as IgE by HDM is well understood, the events that control the initial Th2 polarization in response to HDM are still poorly defined. Notably, mechanisms by which HDM is recognized by the airway mucosa, interacts with barrier epithelial cells, leading to dendritic cell (DC) recruitment, activation, and subsequent Th2-mediated responses, remains to be elucidated. Moreover, whereas the allergenicity of the group 1 major mite allergens could be largely explained by their intrinsic proteolytic activity, the fundamental mechanistic question regarding the putative intrinsic allergenic properties of the group 2 major mite allergen remained unanswered to date.

This review summarizes new insights into diverse determinants that contribute to the HDM allergenicity. In addition to the auto-adjuvant capacity of the two major mite allergen Der p 1 and 2, due to proteolytic activity and functional mimicry of the Toll-like receptor 4 (TLR4) co-receptor MD2 respectively, contaminating factors derived from HDM carriers, mainly endotoxins (LPS) et β-glucans, are very important to activate the innate immune response which, in turns, is involved in the development of allergic response by HDM.