RESEARCH ARTICLE


A Review of the Efficacy and Safety of NasalezeTM in the Prevention and Management of Allergic Rhinitis



Patrick J.D. Bouic*
Division of Medical Microbiology, Dept of Pathology, Faculty of Health Sciences, University of Stellenbosch, P.O. Box 19063, Tygerberg 7505, South Africa.

Article Information


Identifiers and Pagination:

Year: 2008
Volume: 1
First Page: 1
Last Page: 4
Publisher Id: TOALLJ-1-1
DOI: 10.2174/1874838400801010001

Article History:

Received Date: 6/3/2008
Revision Received Date: 5/5/2008
Acceptance Date: 5/5/2008
Electronic publication date: 20/5/2008
Collection year: 2008

© 2008 Patrick J.D. Bouic;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Division of Medical Microbiology, Dept of Pathology, Faculty of Health Sciences, University of Stellenbosch, P.O. Box 19063, Tygerberg 7505, South Africa; Tel: +27-21-9339580; E-mail: pbouic@synexagroup.com


Abstract

NasalezeTM is an inert cellulose powder which has been on sale in the UK since 1994 and is used as a remedy for hay fever. It is applied to the nasal passage where it forms a gelatinous coating, thereby trapping aero-allergens and preventing the initial allergic response. Some limited clinical studies have been conducted in predominantly adults but also in children: outcome measures included the reporting of symptoms by volunteers (sneezing, itching, blocked nose, etc) using questionnaires; prevention of symptoms when challenged to aerosolized allergens; concomitant use of rescue medication and the measurement of inspiratory air flow across the mucosa as well as the release of ECP in nasal washings. The product has been reported to be safe and well tolerated by all volunteers and warrant further investigation in larger studies.